Progressive overload, meaning gradually increasing weight or volume over time, signals the body to maintain and build muscle even during caloric deficit
While the findings are exciting, however, a leading expert in alcohol reduction is calling for caution, pointing out that semaglutide is not licensed for treating alcohol misuse and that established, evidencebased treatments for addiction already exist
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Both factors become relevant when GLP-1 medications alter hydration patterns and appetite-driven fluid consumption
The decline in estrogen slows metabolism, increases fat storage (particularly in the belly), and makes it harder to maintain muscle mass
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