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The article says research indicates estrogen influences GLP-1 signaling at multiple levels, including appetite centers and insulin-producing beta cells

Nearly half of members taking GLP-1s for weight loss discontinued use, compared to about one-third of members taking GLP-1s for diabetes

220 found that the methylation levels of four ER genes including ERO1LB , NFE2L2 , MBTPS1 and EIF2AK4 which encoded ER oxidoreductin-1 (ERO1), nuclear factor-erythroid 2-related factor (Nrf2), site-1 protease (S1P) and eIF-2-alpha kinase (GCN2) respectively, were strongly correlated with total body fat levels

Ledinek AH, Sajko MC, Rot U

Reduces the appearance of dark spots and uneven skin tones

Excessive glutamate release can lead to overexcitation of neurons, leading to anxiety, depression, and other neurological conditions