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Notably, PDOs showed substantial variability across biological replicates, and owing to culture constraints, metabolic inhibitor screening was conducted at a fixed endpoint for all conditions

Future reconstitutions should use the palm-rolling technique exclusively

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Co-ordinated mitochondrial degradation by autophagy and heterophagy in cardiac homeostasis

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There is a theoretical concern that aggressive senolytic clearance could remove this anti-tumor senescence signal, potentially accelerating tumor growth in individuals with pre-malignant cells