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Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]
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Vyleesi (bremelanotide) was FDA-approved in June 2019 for HSDD in premenopausal women based on Phase 3 clinical trial data
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