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As with allopurinol, it is reasonable whenever possible to add a preventative medication, such as colchicine, for at least the first six months after starting febuxostat to help avoid gout flares

In rodents, fragments of the GLP-1 metabolite may also have glucoregulatory effects, possibly mediated through hepatocytes [39], in line with previous observations of degradation of the GLP-1 metabolite [10, 40]

10.1016/j.trci.2018.03.009 51 DadarM.ShahaliY.ChakrabortyS.PrasadM.TahooriF.TiwariR.et al (2019)

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The limits of detection and quantification were 1.8 0.8 g/mL and 5.3 2.3 g/mL, respectively

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