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This work was supported by the Yuhan Innovation Program and the National Research Foundation of Korea (NRF) [2021R1A2C1004669 and RS-2024-00411137], funded by the Korean government (MSIT) and by the KBSI under the R&D program [Project No
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The calibration curve fitting was done by weighted linear regression (1/concentration2)
Its broad signaling profile across multiple pathwaysincluding NO, VEGF, FAK-paxillin, and JAK-2/STAT-3makes it a versatile reference compound in cellular signaling research
Such approaches could better reflect real-world clinical practice and potentially demonstrate benefits that fixed-dose studies might miss
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