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The more efficient conjugation of the QIs to GSH may have reduced covalent modification of cellular macromolecules, like ER proteins Grp78/Bip ( Although reactive QI formation has been associated with AQ-induced (cyto)toxicity in vitro ( in vivo (S5), although DNA ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study ( Figure 7 , AQ-QI and DEAQ-QI exposure resulted in activation of the ER stress response

Through ATF4-mediated integrated stress responses, cancer cells acquire not only drug persistence, ferroptosis sensitivity, and also metastatic phenotype 45,46,47

2020 Aug 25;76(8):1117-1145

M.GiacheliaM.PanieriE.SiminovitchK.GaleottiT.et al (2012)

Butterfield and Rangachari, 1993

54 th ed