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While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency
More recent research continues to support these findings
Back AAAS EurekAlert (18 Dec 2023) 'Toronto study identifies new concepts for GLP-1 action in the brain, the 2023 Science magazine breakthrough of the year'
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Whats worth noting: participants with a BMI of 40 or higher showed similar adherence and percentage of weight lost as those with lower starting BMIs
High doses beyond the typical daily requirement are avoided unless necessary, but there is no evidence of harm to the fetus from normal vitamin B therapy
