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A head-to-head review of clinical studies determined that among available GLP-1 RAs, there were A1C reductions from 0.78% to 1.9%

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one common approach began at 0.5 mg once weekly , with incremental increases at approximately four-weekly intervals up to target maintenance doses of 4 mg, 8 mg, or 12 mg once weekly

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This approach allows adaptation to the compound while minimizing adverse effects during adjustment periods