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Access this article Similar content being viewed by others Abbreviations Amph: Amphetamine AMPT: -Methyl- p -tyrosine ATP: Adenosine triphosphate AUC: Area under the curve C max : Maximum concentration CNS: Central nervous system COMT: Catechol- O -methyltransferase CSF: Cerebrospinal fluid CTX: Cortex CYP: Cytochrome P450 DA: Dopamine DAT: Dopamine transporter DHT: Dihydroxytriptamine DOI: ()-2,5-Dimethoxy-4-iodoamphetamine EC 50 : Effective concentration 50% EU: European Union GABA: Gamma-aminobutyric acid GFAP: Glial fibrillary acidic protein GLU: Glutamate GSH: Glutathione GST: Glutathione S-transferase -GT: gamma-glutamyl transpeptidase or gamma-glutamyltransferase 5-HIAA: 5-Hydroxyindoleacetic acid HIP: Hippocampus HMA: 4-Hydroxy-3-methoxyamphetamine, 3- O -Me--MeDA HMMA: 4-Hydroxy-3-methoxymethamphetamine, 3- O -Me- N -Me--MeDA HO : Hydroxyl radical H 2 O 2 : Hydrogen peroxide 5-HT: 5-Hydroxytriptamine, serotonin 5-HTT: Serotonin transporter HVA: 4-Hydroxy-3-methoxyphenylacetic acid, homovanillic acid i )-methylenedioxymethamphetamine in rat brain

It would also have to stimulate insulin secretion in relevant concentrations and at relevant plasma glucose concentrations, defined as those observed in relation to glucose intake [11]