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An increase in ferroptosis can lead to the death of osteosarcoma cells, suggesting a potential therapeutic approach for osteosarcoma

doi: 10.3389/fpsyt.2021.796466 Received 16 October 2021 Accepted 02 November 2021 Published 30 November 2021 Volume 12 - 2021 Edited by Stefan Borgwardt, University of Lbeck, Germany Reviewed by Alice Egerton, King's College London, United Kingdom Updates Copyright 2021 Palaniyappan, Sabesan, Li and Luo

In vitro, 5-Amino-1MQ at 30 M in 3T3-L1 adipocytes significantly reduced intracellular 1-MNA levels, confirming NNMT target engagement