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Phase 3: Maintenance and Prevention Once the skin is clear, a proactive approach is essential to prevent relapses

Additionally, berberine exhibits anti-inflammatory effects by inhibiting microglial activation, reducing TNF-, IL-1, and IL-6 levels, and attenuating the NF-B pathway in the injured brain (Li et al., 2023a)

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There has been a marked increase in the use of these medications since they were first approved for weight loss in 2014, particularly following the approval of Wegovy in 2021 and Zepbound in 2022

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