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Nootropics, or smart drugs, are a group of supplements that claim to support memory, learning, and focuskind of like a less intense version of the pill from the 2011 film Limitless

Hepatic IR leads to increased liver glucose levels and TG accumulation by weakening insulin-mediated suppression of gluconeogenesis and regulating insulin-mediated TG metabolism, which triggers hyperglycemia and dyslipidemia

This qualified as the only prespecified extreme toxicity (TOX) event per trial protocol (the complete trial protocol is provided in the Supplementary note)