Both GLP-1 and GIP modulate inflammation, with GLP-1 also acting locally to alleviate gut inflammation in part through antiinflammatory actions on GLP-1R + intestinal intraepithelial lymphocytes
Scientific investigations have explored how this selective activation profile may differ from earlier growth hormone secretagogues and contribute to a more targeted stimulation of growth hormone pathways
When to seek medical advice People using semaglutide should see a medical professional regularly throughout treatment to monitor side effects, weight loss, dose effectiveness, and other impacts of the medication
sciencealert.com/semaglutide-may-reverse-damage-caused-by-osteoarthritis-study-suggests Nogrady B
However, weight loss itself increases the risk of gallbladder disease, so its hard to be sure that its the semaglutide thats causing the issue
J Clin Invest 115 : 33933397 Cummings DE and Schwartz MW (2003) Genetics and pathophysiology of human obesity