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MR-PRESSO detected outliers in the overall associations with diabetes, LDL-cholesterol, HDL-cholesterol, apolipoprotein B and diastolic blood pressure, and sex-specific association with LDL-cholesterol, HDL-cholesterol, and apolipoprotein B (shown in Additional file 1: Table S5), where we used corrected estimates from MR-PRESSO

Metformin can increase the risk of lactic acidosis in the setting of excessive alcohol intake, as alcohol impairs the liver's ability to clear lactate

This study aimed to elucidate the role of DNMT1-mediated methylation in transcriptional regulation during MASLD progression and to determine whether DNMT1 inhibition can reverse disease-associated epigenetic and transcriptional alterations

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These subsets may be defined by baseline characteristics, e.g., patients with certain biomarkers, age groups etc., or by post-baseline events, e.g., patients who survived till a certain timepoint, or who responded based on a success criterion