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van der Pouw Kraan TCTM, Chen WJ, Bunck MCM, van Raalte DH, van der Zijl NJ, van Genugten RE, van Bloemendaal L, Baggen JM, Sern EH, Diamant M, Horrevoets AJG (2015) Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity
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Already, GLP-1 weight loss prescriptions Wegovy, Rybelsus and Saxendaalong with Ozempicare the single biggest driver of employer health costs, adding 1% to the total premium expense for 2025, data released last fall from the benefits consultancy Aon said
A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]
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