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Retatrutide also reduced pain in patients with knee osteoarthritis, with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores dropping by as much as 4.5 points, a 75.8% reduction with the 9 mg dose, compared with a 2.4 point (40.3%) reduction for placebo

A slow injection (over 510 seconds) rather than a rapid push also reduces stinging, as it allows the medication to disperse gradually into the tissue rather than creating pressure buildup

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A separate condition, nonarteritic anterior ischemic optic neuropathy (NAION), has also been linked to semaglutide in newer research

Modern formulations allow them to work together safely

Photographs taken monthly in consistent lighting and clothing can also document visible changes that scales may not fully capture