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[163, 165] have reported that off-target toxicity in peripheral organs remained minimal, although they emphasised that excessively high doses or positively charged CQDs may still provoke ROS formation, mitochondrial dysfunction, or the activation of inflammatory pathways [163, 165]
The applied rationale of skin and colon wounds (Seiwerth et al., 1997) covers the different healing patterns and dynamics of these organs related to their collagen structures (Hendriks and Mastboom, 1990)
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At 10mg, clinical trials showed 21.4% average body weight loss, approximately 49 pounds from a 230-pound starting weight