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Studies Investigating IGF-1 and Related Analogs in Cellular and Metabolic Research Models

The six IGFBPs serve as carrier proteins that bind approximately 98% of all circulating native IGF-1, with binding affinity equal to or greater than that of the IGF-1 receptor itself meaning the vast majority of native IGF-1 is sequestered before reaching its receptor

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However, starting later (2-4 weeks post-fracture) still beneficial for remodeling phase