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In rare therapeutic cases, they may contribute to rapid weight changes, but not commonly in regular dosing

Research demonstrates that weight reduction from the compound comes specifically from fat tissue rather than lean body mass

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Overall, this relatively high-quality evidence demonstrates substantial overlap between proportions of patients expected to experience clinically significant improvement from PPS (21% to 56%) compared to from placebo treatment (13% to 49%)

Tendon and ligament repair, gastrointestinal mucosal healing, soft tissue recovery, and neuroprotective signaling are all supported by reproducible rodent and in vitro work, while the human evidence remains limited to one unpublished Phase 2 IBD trial and a small number of preliminary studies