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We note that without information on peoples BMI and underlying medical risk factors, it is not possible to determine whether this reflects a genuine medical need

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Medications like Wegovy and Zepbound must be combined with intensive lifestyle changes, including a reduced-calorie diet and moderate exercise (150 minutes per week), and taken long-term to achieve significant and sustained weight loss

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle