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IGF-1 Des (des(13) IGF-1) is N-Terminally truncated synthetic analog of insulin-like growth factor-1 with deletion of the first three amino acids endowed with lower affinity for insulin-like growth factor binding proteins (IGFBPs) and different interaction kinetics with the receptor

The rationale is based on the peripheral manifestation of neurodegenerative pathology, specifically, the accumulation of misfolded proteins such as phosphorylated -synuclein (P-SYN) in small nerve fibers of the skin

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