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El organismo la produce naturalmente, aunque tambin se integra en el organismo por la ingesta proteica animal y en suplementos alimenticios
Whilst this increase is generally clinically insignificant in healthy individuals, patients with pre-existing tachyarrhythmias or significant cardiac disease should be monitored appropriately
With an even higher hazard ratio than that of the type 2 diabetes group, the analysis again showed a higher risk of NAION for patients on semaglutide who were overweight or obese (hazard ratio: 7.64)
Overall, the data published in the study is not sufficient to establish a causal association between GLP-1RA [semaglutide] use and NAION
Phase 2 trial results that were published in The New England Journal of Medicine included adults who were obese or overweight
In the landmark STEP 1 clinical trial, participants using semaglutide 2.4mg achieved an average body weight reduction of approximately 15% at 68 weeks compared to 2.4% in the lifestyle-only group
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