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The 11.2% discontinuation rate at highest dose is similar to tirzepatide (6-9%) and better than earlier GLP-1 medications

Acknowledgements We thank the 23andMe research participants and employees who made this study possible

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GHRH Co-Dependency for Maximal GH Release Administration of a GHRH antagonist (400 g/kg i.v.) before GHRP-6 (1 g/kg i.v.) in healthy men virtually eliminated the GH response to GHRP-6 reducing the maximal GH increase from 33.8 4.8 to 6.2 1.8 g/L demonstrating that endogenous GHRH is necessary for most of the GH response to GHRP-6 in humans