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Elastin goes up 30%

Available from: Butler J, Shah SJ, Petrie MC, Borlaug BA, Abildstrm SZ, Davies MJ et al (2024) Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials

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Phase 2 showed 9.3% BMI reduction at 14 weeks

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And then we have your participatory athletes your 13 or 14 hour plus IRONMAN finishers in the deepest age groups