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Adiponectin KO (Adipoq / ) (B6;129-Adipoqtm1Chan/J), UCP1 KO (UCP1 / ) (B6.129- Ucp1 tm1Kz /J) mice and their respective wild type controls were purchased from the Jackson Laboratory

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Both peptides remain research tools, and any discussion of dosing, administration strategies, or effects must be understood as mechanistic hypothesis rather than established clinical practice