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A balanced approach is key

[7] The precise contribution of retatrutide's additional receptor activity to blood pressure changes is still being characterised in clinical studies

Include leptin-deficient cohorts if mechanistic generalizability is a goal

Because DSIP has not been thoroughly studied in humans, people who are pregnant or breastfeeding, have significant medical conditions, or take multiple medications should avoid using it unless advised by a qualified healthcare professional

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Koffert J, Honka H, Teuho J, Kauhanen S, Hurme S, Parkkola R, Oikonen V, Mari A, Lindqvist A, Wierup N, et al