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Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease
10.2165/00044011-200525060-00005 Clin Drug Investig
Loading phase: If you are low, treatment often starts with a series of injections (for example, once a week for several weeks) to replenish your body's stores
Autophagy (2021) 17(3):72342
Why Opioids Backfire With Repeated Use With repeated exposure, the nervous system adapts to opioids, leading to: Tolerance , requiring higher doses for the same effect (33,35) Dependence , with withdrawal symptoms when doses wear off (35) Opioid-induced hyperalgesia , a paradoxical increase in pain sensitivity (33,36) Rather than calming pain long term, opioids can sensitize the nervous system, making everyday stimuli feel more painful (33,36)
10.1186/1471-2466-4-13 BMC Pulm Med
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