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Specifically, the highly expressed K430la of ATP-binding cassette subfamily F member 1 (ABCF1) in HCC tissues enhances its nuclear localization, accompanied by its binding to the lysine demethylase 3A (KDM3A) promoter, leading to KDM3A upregulation and subsequent activation of the KDM3A-H3K9me2-HIF1A axis
Growth Horm
In the Transwell invasion assay, a significant increase in the number of membrane-penetrating TPC-1 cells was observed in RRM2 overexpressing group as compared to the control group, and a significant increase in the number of membrane-penetrating cells in the IHH4 cell line, a trend consistent with TPC-1 cells was observed ( Figure 7C , Supplementary Figure S6 )
Longevity Markers Gene-network studies report modulation of stress-response and proteostasis pathways
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