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Based on Phase 2 trial data (Jastreboff et al., NEJM 2023), retatrutide's side effect profile appears broadly consistent with other GLP-1-based therapies, though the addition of glucagon receptor agonism introduces some distinct considerations

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Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated With GLP-1 Receptor Agonists: A Multidisciplinary Expert Consensus

doi: Bader S, Bhatti R, Mussa B, Abusanana S

ArthritisA separate Phase 3 trial, TRIUMPH-4, paired weight loss with knee osteoarthritis

Its primary role is to protect cells from damage caused by free radicals, toxins, and heavy metals