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Molecular mechanisms of synaptic dysregulation in fragile X syndrome and autism spectrum disorders

An evaluation at 34 months of age revealed a global developmental delay with a developmental age of 12 months

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Gene set enrichment analysis (GSEA) was performed with 1000 permutations to identify enriched biological functions and activated pathways from the molecular signatures database (MSigDB), which included hallmark gene sets, positional gene sets, curated gene sets, motif gene sets, computational gene sets, GO gene sets, oncogenic gene sets, and immunologic gene sets

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