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In particular, this was established for such transcription factors as p53 and NF-B, each of which plays a significant role in the mechanisms of proliferation and apoptosis (Yu et al., 2014)

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In the simulation of F347, the ligand adopts the same orientation as in the crystal structure, whereas the orientation of the ligand in the simulation of C347 is varied during the simulation process (the trifluoromethyl-pyrazole group in particular)

Ruppersberg JP, Stocker M, Pongs O, Heinemann SH, Frank R, et al