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The SELECT trial (N=17,604) demonstrated a 20% reduction in major adverse cardiovascular events (MACE) with semaglutide 2.4 mg compared with placebo over a mean follow-up of 39.8 months [4]

One obvious advantage of the small molecule agonists in the replacement of peptide GLP-1 analogues is that they could be administered orally, thus avoiding the discomfort of subcutaneous injections and increasing the compliance of patients

Long-term benefits (8-12 weeks and beyond) could include cardiovascular improvements, reduced scarring after injuries, and better gastrointestinal health, among other things

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