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[4] Whilst these incretin-based therapies offer significant metabolic benefits, they commonly affect gastrointestinal function, including bowel movements

As mentioned in the previous section, according to a 2020 meta-analysis published in Clinical Nutrition ESPEN, berberine may help to lower body weight and obesity and improve metabolic parameters ( 6 )

These are typically manageable but can be uncomfortable and disruptive

Its worth noting that weight loss and changes in diet can also play a role in mood changes

Taking the capsules after meals enriched with healthy fats improves absorption due to the lipid nature of the formulation