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The amount of estradiol produced during the menstrual cycle varies a lot in different women (see Panel A of Figure 3)

5f revealed that 2016 unique genes were exclusively expressed in PBS group as compared to sham hamster, whereas only unique 415 differentially expressed genes were found between the LSC-Exo and sham groups

This mechanism is not fully elucidated and it is possible that it acts via the IGF-1 receptor (not GHR) in localized concentrations