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Hepatology 59 (5), 17381749

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Empagliflozin lowers serum uric acid in chronic kidney disease: exploratory analyses from the EMPA-KIDNEY trial

The mammalian ortholog, casein kinase 1 alpha (CSNK1A1), is known to prime substrates for E3 ligase recognition by phosphorylating short amino acid sequences called phospho-degrons, which leads to ubiquitination and rapid proteasomal degradation 70,76,77,87,89