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Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

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27(4):299311 Physiological role of insulin-like growth factor I in endocrine and growth-related signaling pathways Disclaimer: For Laboratory Research Use Only (RUO)

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