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Figure 2: Around half of GLP-1 side effects are gastrointestinal GLP-1s have previously been suggested to be linked to self-harm and suicidal thoughts, but the MHRA concluded in September 2024 that the available data do not support a causal association between GLP-1s and depression, suicidal ideation and suicide, following a review by the European Medicines Agencys pharmacovigilance risk assessment committee 24
Analyses were conducted using non-compartmental methods in the statistical software SAS, version 9.4 M5
But besides simply not pooping regularly, constipation from semaglutide and other GLP-1 medications can present as: Fewer than three bowel movements per week Hard, dry, or lumpy stools Straining during bowel movements Feeling of incomplete evacuation Abdominal discomfort or bloating Hard stool followed by watery loose stool Its important to distinguish between occasional constipation (which is common) and chronic constipation , which may require assistance to address the cause