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In order to build our MSM, we split the conformational space using the Voronoi decomposition, clustering the ligands center of mass and using the cluster centers as seeds

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The separation via HPLC follows an isocratic method at 30 C using a reversed-phase column in two runs

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This approach helps maintain DSIP's stability and efficacy for up to four weeks when stored in refrigeration between 36 to 46F (2 to 8C)