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The exact mechanism for this is not fully established, but hypotheses include compensatory responses to blood pressure reduction or direct effects on autonomic tone

Seiwerth, Sven et al

Phase Cag introduction Weeks 9-12 Retatrutide 4 mg/week (hold) Cagrilintide 0.25 mg/week Notes Add cagrilintide at the lowest dose

Retrieved 14 May 2022, from A Phase III, Multicentre, Double-Blind, Randomized, Placebo-Controlled Study to Confirm the Safety and Efficacy of Subcutaneous Bioresorbable Afamelanotide Implants in Patients with Erythropoietic Protoporphyria (EPP)

Frontiers in Chemistry, 11

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