T2DM is associated with fluctuating hyperglycemia despite optimal medical treatment 8,9
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The -glutamyl cycle was initially postulated by Meister as a mechanism for amino acid transport ( in vivo caused a decrease in amino acid transfer into cells
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According to protein structure predictions 23 , they also adopt the thioredoxin fold, which puts the putative active site, a CCMC/S or CCLC/S motif, at the beginning of helix 1 (shown exemplarily for ROXY9 in Fig