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Additionally, the absence of microbiota, or the presence of broad-spectrum antibiotic-induced dysbiosis, triggered the NOD-like receptor family pyrin domain (PYD)-containing 6 (NLRP6)/Caspase 11 (Casp11) inflammasome-mediated pathway and subsequent loss of iEANs and enteric neuropathy (Muller et al., 2020a)

The FTO rs9939609 variant correlates with increased appetite drive and metabolic efficiency, meaning carriers may genuinely require different therapeutic approaches than population averages suggest

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Avoid temperature above 40C