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In order to continue tumor growth, oncogenes or carcinogenic signaling contribute to avoid ferroptosis and thus also allow resistance toward treatments ( In ferroptosis resistant melanoma cells, CHAC1 was shown to be upregulated by NRF2 independent from ER stress signaling alongside the Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) capable of degrading lipid radicals ( CHAC1 , most melanoma cell lines appear to be resistant against ferroptosis
Trends Endocrinol Metab 10 : 229235 Baldissera FG and Holst JJ (1984) Glucagon-related peptides in the human gastrointestinal mucosa
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The study found that this class of medications significantly increases the risk of developing gastroparesis and other gastrointestinal disorders
Manee-In S et al
(2024) 3:e244369
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