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Discussion In this paper, we develop the first mathematical model of the GSH antioxidant system in the outer retina, capturing the most essential components for ROS creation, GSH production, oxidation in neutralizing ROS, and reduction as well as the diversion of glucose into the PPP to synthesize NADPH
NAC has shown benefit as adjunctive therapy in some trials
Additionally, gaining approval for obesity treatment, especially in non-diabetic populations, can be more stringent due to concerns over long-term safety and cost-effectiveness
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