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5-fluorouracil enhances the antitumor activity of the glutaminase inhibitor cb-839 against pik3ca-mutant colorectal cancers

[12] [13] Practical hygiene measures can significantly reduce candidal colonisation: Wear loose-fitting, breathable cotton underwear and avoid synthetic fabrics that trap moisture Change out of wet clothing promptly , particularly after exercise or swimming Avoid perfumed soaps, bubble baths, and vaginal douches , which disrupt natural flora Maintain good genital hygiene without over-washing, which can remove protective bacteria Ensure the genital area is thoroughly dried after bathing A balanced diet supporting good glycaemic control may help reduce infection risk

A 2025 intravenous safety study involving two healthy adults found infusions up to 20 mg well tolerated, with no adverse events or clinically meaningful changes in vital signs or laboratory biomarkers

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