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The drug performed significantly better than a placebo, with people on the highest dose losing around 10% of their baseline body weight on average

This observation seems particularly important since misfolded proteins might lose in vivo potency and be subject to enhanced proteolysis and potential immunogenicity

Reproductive longevity and aging: geroscience approaches to maintain long-term ovarian fitness

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For weight management (Zepbound), the same titration applies

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