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Saxenda was also noted to cause hypoglycemia (low blood sugar) when used with some other anti-diabetic drugs (sulfonylureas)

Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control

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[18] [19] Patients should seek prompt medical advice if they develop right upper abdominal pain, fever, or jaundice

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