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While the laxative effects of magnesium are typically seen at doses of around 400 milligrams, Hamilton recommends starting lower, around 200 milligrams, to reduce the risk of diarrhea

Similarly, another smaller study, BEDIP, with a shorter duration, found improvements in a combined neuropathic symptom and sign score after 3 weeks of treatment with 400 mg of benfotiamine daily [72]

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Both promote angiogenesis through different pathways, creating additive effects on blood vessel formation

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Although NAION was rare and the event rate was low, an elevated risk was found in this study