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3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression

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It remains to be elucidated exactly how the GCGRs can respond to GLP-1(936) in the presence of the high intra-islet glucagon levels

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10.1007/s00775-018-1539-7 42 KusumkarV