Changes in HbA1c in participants with pre-existing pre-diabetes between treatment arms, and in participants with pre-existing T2D between treatment arms, was assessed with the inclusion of an interaction term between diabetes status and treatment allocation in the linear regression model for HbA1c and calculated from estimated marginal means
PLP is positively associated with kynurenic acid, 3-hydroxyanthranilic acid and xanthurenic acid, all formed by PLP-based enzymes, and negatively associated with 3-hydroxykynurenine, metabolized by PLP-based enzymes
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